Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives - Aix-Marseille Université Access content directly
Journal Articles Molecules Year : 2013

Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Abstract

We report herein the first synthesis of propargylic alcohols using an organic reducing agent. Diarylbutynol derivatives are formed in moderate to good yields under mild conditions from the reaction of 1-(3-chloroprop-1-ynyl)-4-nitrobenzene with various aromatic aldehydes using tetrakis(dimethylamino) ethylene (TDAE) as reductant.
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hal-01460469 , version 1 (29-06-2023)

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Manon Roche, Thierry Terme, Patrice Vanelle. Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives. Molecules, 2013, 18 (2), pp.1540--1548. ⟨10.3390/molecules18021540⟩. ⟨hal-01460469⟩
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