New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm
(1)
,
Brent A.Orr
(2)
,
Umut H.Toprak
(1)
,
Volker Hovestadt
(1)
,
David T. W. Jones
(1)
,
David Capper
(3)
,
Martin Sill
(1)
,
Ivo Buchhalter
(1)
,
Paul A.Northcott
(1)
,
Irina Leis
(1)
,
Marina Ryzhova
(1)
,
Christian Koelsche
(4)
,
Elke Pfaff
(1)
,
Sariah J.Allen
(2)
,
Gnanaprakash Balasubramanian
(1)
,
Barbara C. Worst
(1)
,
Kristian W. Pajtler
(1)
,
Sebastian Brabetz
(1)
,
Pascal D. Johann
(1)
,
Felix Sahm
(1)
,
Jüri Reimand
(5)
,
Alan Mackay
(6)
,
Diana M. Carvalho
(6)
,
Marc Remke
(5)
,
Joanna J. Phillips
(7)
,
Arie Perry
(7)
,
Cynthia Cowdrey
(7)
,
Rachid Drissi
(8)
,
Maryam Fouladi
(8)
,
Felice Giangaspero
(9)
,
Maria Łastowska
(10)
,
Wiesława Grajkowska
(10)
,
Wolfram Scheurlen
(11)
,
Torsten Pietsch
(12)
,
Christian Hagel
(13)
,
Johannes Gojo
(14)
,
Daniela Lötsch
(14)
,
Walter Berger
(14)
,
Irene Slavc
(14)
,
Christine Haberler
(14)
,
Anne Jouvet
(15)
,
Stefan Holm
(16)
,
Silvia Hofer
(17)
,
Marco Prinz
(18)
,
Catherine Keohane
(19)
,
Iris Fried
(20)
,
Christian Mawrin
(21)
,
David Scheie
(22)
,
Bret C. Mobley
(23)
,
Matthew J.Schniederjan
(24)
,
Mariarita Santi
(25)
,
Anna M. Buccoliero
(26)
,
Sonika Dahiya
(27)
,
Christof M. Kramm
(28)
,
André O. von Bueren
(28)
,
Katja von Hoff
(13)
,
Stefan Rutkowski
(13)
,
Christel Herold-Mende
(1)
,
Michael C. Frühwald
(29)
,
Till Milde
(1)
,
Martin Hasselblatt
(30)
,
Pieter Wesseling
(31)
,
Jochen Rössler
(32)
,
Ulrich Schüller
(33)
,
Martin Ebinger
(34)
,
Jens Schittenhelm
(34)
,
Stephan Frank
(35)
,
Rainer Grobholz
(36)
,
Istvan Vajtai
(37)
,
Volkmar Hans
(38)
,
Reinhard Schneppenheim
(13)
,
Karel Zitterbart
(39)
,
Peter V. Collins
(40)
,
Eleonora Aronica
(41)
,
Pascale Varlet
(42)
,
Jacques Grill
(43, 44)
,
Stephanie Puget
(45)
,
Christelle Dufour
(44, 43)
,
Dominique Figarella-Branger
(46)
,
Marietta Wolter
(33)
,
Martin U. Schuhmann
(33)
,
Tarek Shalaby
(47)
,
Michael Grotzer
(47)
,
Timothy van Meter
(48)
,
Camelia-Maria Monoranu
(49)
,
Jörg Felsberg
(50)
,
Guido Reifenberger
(50)
,
Matija Snuder
(50)
,
Lynn Ann Forrester
(51)
,
Jan Koster
(41)
,
Rogier Versteeg
(52)
,
Richard Volckmann
(52)
,
Peter van Sluis
(52)
,
Stephan Wolf
(1)
,
Tom Mikkelsen
(53)
,
Amar Gajjar
(2)
,
Kenneth Aldape
(54)
,
Andrew S. Moore
(55)
,
Michael D. Taylor
(5)
,
Chris Jones
(6)
,
Nada Jabado
(56)
,
Matthias A. Karajannis
(51)
,
Roland Eils
(1)
,
Matthias Schlesner
(1)
,
Peter Lichter
(1)
,
Andreas von Deimling
(2)
,
Stefan M. Pfister
(1)
,
David W. Ellison
(2)
,
Andrey Korshunov
(1)
,
Marcel Kool
(1)
1
Heidelberg University Hospital [Heidelberg]
2 St Jude Children's Research Hospital
3 Department of Neuropathology
4 NNBNI - NN Burdenko Neurosurgical Institute
5 University of Toronto
6 The Institute of Cancer Research
7 UC San Francisco - University of California [San Francisco]
8 Children's Hospital Medical Center
9 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
10 The Children's Memorial Health Institute
11 Cnopf’sche Kinderklinik -
12 Universität Bonn = University of Bonn
13 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
14 Medizinische Universität Wien = Medical University of Vienna
15 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
16 Karolinska Institutet [Stockholm]
17 Luzerner Kantonsspital
18 Albert-Ludwigs-Universität Freiburg = University of Freiburg
19 Cork University Hospital
20 Hadassah Hebrew University Medical Center [Jerusalem]
21 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
22 Rigshospitalet [Copenhagen]
23 Vanderbilt University [Nashville]
24 Children’s Healthcare of Atlanta
25 CHOP - Children’s Hospital of Philadelphia
26 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
27 WUSTL - Washington University in Saint Louis
28 UMG - University Medical Center Göttingen
29 Klinikum Augsburg
30 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
31 Radboud University Medical Center [Nijmegen]
32 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
33 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
34 Tübingen University Hospital [Germany]
35 University Hospital Basel [Basel]
36 Hirslanden Medical Center
37 University Hospital Berne
38 Medical Center Bielefeld
39 MUNI - Masaryk University [Brno]
40 Department of Pathology
41 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
42 Hôpital d'Instruction des Armées Sainte Anne
43 IGR - Institut Gustave Roussy
44 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
45 Hôpital Necker - Enfants Malades [AP-HP]
46 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
47 University hospital of Zurich [Zurich]
48 VCU - Virginia Commonwealth University
49 Biocenter University of Würzburg = Biozentrum der Universität Würzburg
50 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
51 NYU Langone Medical Center - New York University Langone Medical Center
52 VU University Medical Center [Amsterdam]
53 Henry Ford Hospital
54 The University of Texas M.D. Anderson Cancer Center [Houston]
55 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
56 McGill University = Université McGill [Montréal, Canada]
2 St Jude Children's Research Hospital
3 Department of Neuropathology
4 NNBNI - NN Burdenko Neurosurgical Institute
5 University of Toronto
6 The Institute of Cancer Research
7 UC San Francisco - University of California [San Francisco]
8 Children's Hospital Medical Center
9 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
10 The Children's Memorial Health Institute
11 Cnopf’sche Kinderklinik -
12 Universität Bonn = University of Bonn
13 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
14 Medizinische Universität Wien = Medical University of Vienna
15 Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
16 Karolinska Institutet [Stockholm]
17 Luzerner Kantonsspital
18 Albert-Ludwigs-Universität Freiburg = University of Freiburg
19 Cork University Hospital
20 Hadassah Hebrew University Medical Center [Jerusalem]
21 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
22 Rigshospitalet [Copenhagen]
23 Vanderbilt University [Nashville]
24 Children’s Healthcare of Atlanta
25 CHOP - Children’s Hospital of Philadelphia
26 UniFI - Università degli Studi di Firenze = University of Florence = Université de Florence
27 WUSTL - Washington University in Saint Louis
28 UMG - University Medical Center Göttingen
29 Klinikum Augsburg
30 UKM - University Hospital Münster - Universitaetsklinikum Muenster [Germany]
31 Radboud University Medical Center [Nijmegen]
32 Uniklinik - Universitäts Klinikum Freiburg = University Medical Center Freiburg
33 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
34 Tübingen University Hospital [Germany]
35 University Hospital Basel [Basel]
36 Hirslanden Medical Center
37 University Hospital Berne
38 Medical Center Bielefeld
39 MUNI - Masaryk University [Brno]
40 Department of Pathology
41 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
42 Hôpital d'Instruction des Armées Sainte Anne
43 IGR - Institut Gustave Roussy
44 Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy]
45 Hôpital Necker - Enfants Malades [AP-HP]
46 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
47 University hospital of Zurich [Zurich]
48 VCU - Virginia Commonwealth University
49 Biocenter University of Würzburg = Biozentrum der Universität Würzburg
50 Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf]
51 NYU Langone Medical Center - New York University Langone Medical Center
52 VU University Medical Center [Amsterdam]
53 Henry Ford Hospital
54 The University of Texas M.D. Anderson Cancer Center [Houston]
55 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
56 McGill University = Université McGill [Montréal, Canada]
Anne Jouvet
- Fonction : Auteur
- PersonId : 942866
Pascale Varlet
- Fonction : Auteur
- PersonId : 762020
- ORCID : 0000-0002-8164-1517
Dominique Figarella-Branger
- Fonction : Auteur
- PersonId : 18293
- IdHAL : dominique-figarella-branger
- ORCID : 0000-0002-3604-887X
- IdRef : 067213642
Résumé
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated “CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2),” “CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC),” “CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1),” and “CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR),” will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.
| Origine | Accord explicite pour ce dépôt |
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