NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice - Aix-Marseille Université Access content directly
Journal Articles American Journal of Respiratory and Critical Care Medicine Year : 2009

NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice

Abstract

Hyperoxia-induced acute lung injury has been used for many years as a model of oxidative stress mimicking clinical acute lung injury and the acute respiratory distress syndrome. Excess quantities of reactive oxygen species (ROS) are responsible for oxidative stress-induced lung injury. ROS are produced by mitochondrial chain transport, but also by NADPH oxidase (NOX) family members. Although NOX1 and NOX2 are expressed in the lungs, their precise function has not been determined until now.

Dates and versions

hal-01744666 , version 1 (27-03-2018)

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Stéphanie Carnesecchi, Christine Deffert, Alessandra Pagano, Sarah Garrido-Urbani, Isabelle Métrailler-Ruchonnet, et al.. NADPH Oxidase-1 Plays a Crucial Role in Hyperoxia-induced Acute Lung Injury in Mice. American Journal of Respiratory and Critical Care Medicine, 2009, 180 (10), pp.972 - 981. ⟨10.1164/rccm.200902-0296OC⟩. ⟨hal-01744666⟩
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