Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis - Aix-Marseille Université Access content directly
Journal Articles Epigenomics Year : 2017

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Abstract

Aim: Homocysteine (Hcy) is a sensitive marker of one-carbon metabolism. Higher Hcy levels have been associated with global DNA hypomethylation. We investigated the association between plasma Hcy and epigenome-wide DNA methylation in leukocytes. Methods: Methylation was measured using Illumina 450 k arrays in 2035 individuals from six cohorts. Hcy-associated differentially methylated positions and regions were identified using meta-analysis. Results: Three differentially methylated positions cg21607669 (SLC27A1), cg26382848 (AJUBA) and cg10701000 (KCNMA1) at chromosome 19, 14 and 10, respectively, were significantly associated with Hcy. In addition, we identified 68 Hcy-associated differentially methy-lated regions, the most significant of which was a 1.8-kb spanning domain (TNXB/ATF6B) at chromosome 6. Conclusion: We identified novel epigenetic loci associated with Hcy levels, of which specific role needs to be further validated.
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Dates and versions

hal-01753870 , version 1 (11-04-2018)

Identifiers

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Pooja R Mandaviya, Dylan Aïssi, Koen F Dekkers, Roby Joehanes, Silva Kasela, et al.. Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics, 2017, 9 (11), pp.1403-1422. ⟨10.2217/epi-2017-0038⟩. ⟨hal-01753870⟩
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