Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Journal of Immunology Année : 2017

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry

Résumé

Sustained Ca2+ signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8(+) T cells require sustained Ca2+ signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca2+ signaling to murine NK cell function. Surprisingly, we found that, although SOCE is required for NK cell IFN-gamma production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo remained intact in the absence of sustained Ca2+ signaling. Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.

Domaines

Immunologie
Fichier principal
Vignette du fichier
nihms896553.pdf (535.49 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01765105 , version 1 (10-07-2024)

Identifiants

Citer

Jacquelyn Freund-Brown, Ruth Choa, Brenal K. Singh, Tanner Ford Robertson, Gabrielle M. Ferry, et al.. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. Journal of Immunology, 2017, 199 (6), pp.1973-1978. ⟨10.4049/jimmunol.1700340⟩. ⟨hal-01765105⟩

Collections

CNRS UNIV-AMU
20 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More