Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target - Aix-Marseille Université Access content directly
Journal Articles Toxins Year : 2012

Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target


Deoxynivalenol (DON), mainly produced by Fusarium fungi, and also commonly called vomitoxin, is a trichothecene mycotoxin. It is one of the most abundant trichothecenes which contaminate cereals consumed by farm animals and humans. The extent of cereal contamination is strongly associated with rainfall and moisture at the time of flowering and with grain storage conditions. DON consumption may result in intoxication, the severity of which is dose-dependent and may lead to different symptoms including anorexia, vomiting, reduced weight gain, neuroendocrine changes, immunological effects, diarrhea, leukocytosis, hemorrhage or circulatory shock. During the last two decades, many studies have described DON toxicity using diverse animal species as a model. While the action of the toxin on peripheral organs and tissues is well documented, data illustrating its effect on the brain are significantly less abundant. Yet, DON is known to affect the central nervous system. Recent studies have provided new evidence and detail regarding the action of the toxin on the brain. The purpose of the present review is to summarize critical studies illustrating this central action of the toxin and to suggest research perspectives in this field.
Fichier principal
Vignette du fichier
toxins-04-01120.pdf (1.78 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-01768304 , version 1 (17-04-2018)





Marion Bonnet, Julien Roux, Lourdes Mounien, Michel Dallaporta, Jean-Denis Troadec. Advances in Deoxynivalenol Toxicity Mechanisms: The Brain as a Target. Toxins, 2012, 4 (11), pp.1120-1138. ⟨10.3390/toxins4111120⟩. ⟨hal-01768304⟩
197 View
67 Download



Gmail Facebook X LinkedIn More