Chapitre D'ouvrage Année : 2018

Electron Transfer in Catalases and Catalase-Peroxidases

Résumé

Catalases (EC 1.11.1.6) are enzymes that catalyze the disproportionation of hydrogen peroxide into water and molecular oxygen by means of a heme iron or a dimanganese active site. They are crucial metalloproteins regulating the cellular concentration of hydrogen peroxide, which has a concentration-dependent dual role in cell signaling and oxidative stress. Catalase-peroxidases, also named KatGs from the encoding katG gene, are heme-containing oxidoreductases capable of both the disproportionation of hydrogen peroxide and the oxidation of substrates via high-valent heme intermediates. KatGs also generate superoxide via an oxidase reaction and activate the antitubercular prodrug isoniazid (INH) through its conversion to isonicotinyl-NAD.

Fichier non déposé

Dates et versions

hal-01798212 , version 1 (23-05-2018)

Identifiants

Citer

Anabella Ivancich, Peter C. Loewen. Electron Transfer in Catalases and Catalase-Peroxidases. Encyclopedia of Biophysics, , 2018, 978-3-642-35943-9. ⟨10.1007/978-3-642-35943-9_51-1⟩. ⟨hal-01798212⟩

Collections

173 Consultations
0 Téléchargements

Altmetric

Partager

  • More