Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper. - Aix-Marseille Université Access content directly
Journal Articles Biological Trace Element Research Year : 1992

Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.

Abstract

Carboxy-terminal amidation of biologically active peptides, an important characteristic of more than half of these substances, occurs during the maturation process of peptide precursors. It is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme that is copper-dependent. We show here that alterations of copper stores in cultured cells from different origins (pancreas and hypothalamus) affect the immunoreactivity of thyrotropin-releasing hormone (TRH) and corticotropin-releasing factor (CRF) (two alpha-amidated peptides). This suggests that copper can affect neuropeptide biosynthesis and may play a role in the endocrine or central nervous system function.

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Cancer
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hal-01803479 , version 1 (30-05-2018)

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  • HAL Id : hal-01803479 , version 1
  • PUBMED : 1375068

Cite

P. Giraud, M Maltèse, F. Boudouresque, P. Salers, L Ouafik, et al.. Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.. Biological Trace Element Research, 1992, pp.293-301. ⟨hal-01803479⟩

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