Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations? - Aix-Marseille Université Access content directly
Journal Articles The Journal of Physiology Year : 2010

Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations?

Abstract

Several patterns of coherent activity have been described in developing cortical structures, thus providing a general framework for network maturation. A detailed timely description of network patterns at circuit and cell levels is essential for the understanding of pathogenic processes occurring during brain development. Disturbances in the expression timetable of this pattern sequence are very likely to affect network maturation. This review focuses on the maturation of coherent activity patterns in developing neocortical structures. It emphasizes the intrinsic and synaptic cellular properties that are unique to the immature neocortex and, in particular, the critical role played by extracellular glutamate in controlling network excitability and triggering synchronous network waves of activity.
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Dates and versions

hal-01848197 , version 1 (27-08-2018)

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Camille Allène, Rosa Cossart. Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations?. The Journal of Physiology, 2010, 588 (1), pp.83-91. ⟨10.1113/jphysiol.2009.178798⟩. ⟨hal-01848197⟩

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