The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice - Aix-Marseille Université Access content directly
Journal Articles eLife Year : 2018

The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice

Abstract

Brain computations rely on a proper balance between excitation and inhibition which progressively emerges during postnatal development in rodent. g-Aminobutyric acid (GABA) neurotransmission supports inhibition in the adult brain but excites immature rodent neurons. Alterations in the timing of the GABA switch contribute to neurological disorders, so unveiling the involved regulators may be a promising strategy for treatment. Here we show that the adipocyte hormone leptin sets the tempo for the emergence of GABAergic inhibition in the newborn rodent hippocampus. In the absence of leptin signaling, hippocampal neurons show an advanced emergence of GABAergic inhibition. Conversely, maternal obesity associated with hyperleptinemia delays the excitatory to inhibitory switch of GABA action in offspring. This study uncovers a developmental function of leptin that may be linked to the pathogenesis of neurological disorders and helps understanding how maternal environment can adversely impact offspring brain development.

Keywords

Fichier principal
Vignette du fichier
Dumon et al elife 2018.pdf (1.18 Mo) Télécharger le fichier
Origin Publication funded by an institution
Loading...

Dates and versions

hal-01963638 , version 1 (21-12-2018)

Licence

Identifiers

  • HAL Id : hal-01963638 , version 1

Cite

Marlene Bartos, Camille Dumon, Diabe Diabira, Ilona Chudotvorova, Francesca Bader, et al.. The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice. eLife, 2018, 7. ⟨hal-01963638⟩

Collections

INSERM UNIV-AMU
101 View
105 Download

Share

Gmail Mastodon Facebook X LinkedIn More