The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review - Aix-Marseille Université Access content directly
Journal Articles Basic and Clinical Andrology Year : 2018

The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review

Abstract

The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of proteins and is required for normal nuclear structure and physiological development. During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. There is mounting evidence from studies in human and rodent, that the NL plays an important role in mammalian spermatid differentiation during spermiogenesis. In this review, we summarize and discuss the data available in the literature regarding the involvement of lamins and their direct or indirect partners in normal and abnormal human spermiogenesis.

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Human genetics
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Dates and versions

hal-01991356 , version 1 (23-01-2019)

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  • HAL Id : hal-01991356 , version 1

Cite

Marine Paci, Razan A. Elkhatib, Guy Longepied, Patrice Bourgeois, Pierre F. Ray, et al.. The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review. Basic and Clinical Andrology, 2018, 28. ⟨hal-01991356⟩

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