High burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia: The French Familial Hypercholesterolemia Registry - Aix-Marseille Université Access content directly
Journal Articles Atherosclerosis Year : 2018

High burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia: The French Familial Hypercholesterolemia Registry

1 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
2 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
3 CHU Saint-Antoine [AP-HP]
4 CRSA - Centre de Recherche Saint-Antoine
5 ITX - ITX - unité de recherche de l'institut du thorax
6 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
7 CHU Pitié-Salpêtrière [AP-HP]
8 I2MC - Institut des Maladies Métaboliques et Cardiovasculaires
9 Point médical (Dijon)
10 LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
11 Hôpital Guillaume et René Laennec - Centre Hospitalier Universitaire de Nantes
12 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
13 Hôpital Ambroise Paré [AP-HP]
14 NORT - Nutrition, obésité et risque thrombotique
15 LVTS (UMR_S_1148 / U1148) - Laboratoire de Recherche Vasculaire Translationnelle
16 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
17 CHU Tenon [AP-HP]
18 Rythmes Biologiques et Cancers
19 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
20 N2C - Nutrition Croissance et Cancer
21 PhyMedExp - Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
22 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
23 Maladies Métaboliques et Endocrinologie
24 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
Jean Pierre Rabès
  • Function : Author
  • PersonId : 894506
Alexandre Vimont
  • Function : Author
D. Angoulvant
  • Function : Author
S. Beliard
  • Function : Author
P. Benlian
  • Function : Author
C. Boileau
  • Function : Author
V. Carreau
  • Function : Author
P. Ducluzeau
E. Ferrari
  • Function : Author
A. Gallo
P. Girardet
  • Function : Author
D. Lalau
  • Function : Author
B. Lefort
  • Function : Author
J. Lemale
  • Function : Author
P. Moulin
  • Function : Author
F. Paillard
  • Function : Author
A. Pradignac
  • Function : Author
Y. Pucheu
  • Function : Author
S. Saheb
  • Function : Author
P. Tounian
  • Function : Author
C. Yelnik
  • Function : Author
O. Ziegler
  • Function : Author

Abstract

Background and aims: Cardiovascular risk is high in heterozygous familial hypercholesterolemia (HeFH). The objective of this study was to describe recurrent cardiovascular events in selected patients with HeFH attending lipid clinics in France. Methods: We included 781 patients with a clinical (Dutch Lipid Clinic Network score >= 6) or genetic diagnosis of HeFH who had experienced a first cardiovascular event (myocardial infarction, percutaneous coronary intervention or coronary bypass, unstable angina, stroke, peripheral arterial revascularization or cardiovascular death) and were enrolled in the French Familial Hypercholesterolemia Registry (November 2015 to March 2018). Results: The first cardiovascular event occurred at the mean age of 47 years (interquartile range 39-55) in a predominantly male population (72%); 48% of patients were on statin therapy. Overall, 37% of patients had at least one recurrent cardiovascular event (mean of 1.8 events per patient), of which 32% occurred in the 12 months after the index event; 55% of events occurred > 3 years after the first event. Mean LDL-C at the last clinic visit was 144 +/- 75 mg/dL (132 +/- 69 mg/dL for patients on high-potency statin therapy and 223 +/- 85 mg/dL for untreated patients). Conclusions: The rate of recurrent cardiovascular events was high in French patients with HeFH in secondary prevention. The detection of FH during childhood is crucial to prevent CV events at a young age by early initiating statin therapy. There is a clear urgent need to expand the actual very small target population which can be treated with the PCSK9 inhibitor in France.
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hal-01996274 , version 1 (01-02-2019)

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Sophie Béliard, Franck Boccara, Bertrand Cariou, Alain Carrié, Xavier Collet, et al.. High burden of recurrent cardiovascular events in heterozygous familial hypercholesterolemia: The French Familial Hypercholesterolemia Registry. Atherosclerosis, 2018, 277, pp.334-340. ⟨10.1016/j.atherosclerosis.2018.08.010⟩. ⟨hal-01996274⟩
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