Ketogenic Ratio Determines Metabolic Effects of Macronutrients and Prevents Interpretive Bias - Aix-Marseille Université Access content directly
Journal Articles Frontiers in Nutrition Year : 2018

Ketogenic Ratio Determines Metabolic Effects of Macronutrients and Prevents Interpretive Bias

Abstract

Thomas Seyfried remarked in his book [(1), page 6]: “The definition of ketogenic diet allows for considerable leeway in food choices as long as the individual has reduced blood glucose and is producing ketones.” Unfortunately, these parameters are lacking in many if not most of studies into metabolic effects of macronutrients. Meanwhile, there is a precise way to predict whether or not a diet will induce ketosis and the aim of this opinion article is to advocate a broader usage of this way. Why is this so important? Excess of carbohydrate intake typical for consumers of the Western diet may cause detrimental effects on metabolism and increase risks of the onset and progression of many neurodegenerative diseases (2–4). On the other hand, diets high in fat and low in carbohydrates decrease appetite, probabilities of food addiction and obesity, and are neuroprotective (5, 6). Carbohydrate restriction induces physiological changes which are very similar to the well documented beneficial effects of calorie restriction (7, 8). Conversely, the hallmark of high-carbohydrate diets is homeostatic inadequacy (9), an overproduction of reactive oxygen species and advanced glycation products, both of which are implicated in neuroinflammation and neurodegeneration (10–12). However, the meaning of “high” or “low” in diets' definition has been drifting away from the previously established quantitative criterion known as ketogenic ratio.
Fichier principal
Vignette du fichier
fnut-05-00075.pdf (801.22 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02335412 , version 1 (28-10-2019)

Licence

Attribution

Identifiers

Cite

Tanya Zilberter, Yuri Zilberter. Ketogenic Ratio Determines Metabolic Effects of Macronutrients and Prevents Interpretive Bias. Frontiers in Nutrition, 2018, 5, ⟨10.3389/fnut.2018.00075⟩. ⟨hal-02335412⟩

Collections

UNIV-AMU INS
75 View
111 Download

Altmetric

Share

Gmail Facebook X LinkedIn More