Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities - Aix-Marseille Université Access content directly
Journal Articles Iranian Journal of Pharmaceutical Research Year : 2019

Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities

Abstract

Some new β-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino β-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC 50 values.
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Dates and versions

hal-02392394 , version 1 (04-12-2019)

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Aliasghar Jarrahpoura, Roghayeh Heirana, Véronique Sinouc, Christine Latourc, Lamia Djouhri Bouktabd, et al.. Synthesis of New β-Lactams Bearing the Biologically Important Morpholine Ring and POM Analyses of Their Antimicrobial and Antimalarial Activities. Iranian Journal of Pharmaceutical Research, 2019, 18 (1), pp.34-48. ⟨10.22037/ijpr.2019.2348⟩. ⟨hal-02392394⟩

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