GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch - Aix-Marseille Université Access content directly
Journal Articles Journal of Cell Biology Year : 2020

GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch

Abstract

The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201903033 ) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS.

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Neurobiology
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Dates and versions

hal-02439594 , version 1 (14-01-2020)

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Attribution - NonCommercial - ShareAlike

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Christophe Leterrier. GABA in, garbage out: AIS-located proteasomes regulate the developmental GABA switch. Journal of Cell Biology, 2020, 219 (2), ⟨10.1083/jcb.201912006⟩. ⟨hal-02439594⟩
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