Diabetes in patients with acromegaly treated with pegvisomant: observations from acrostudy - Aix-Marseille Université Access content directly
Journal Articles Endocrine Year : 2019

Diabetes in patients with acromegaly treated with pegvisomant: observations from acrostudy

Aart Jan van Der Lely
  • Function : Author
Ann Charlotte Akerblad
  • Function : Author
Maria Koltowska-Haeggstrom
  • Function : Author
Roy Gomez
  • Function : Author
Michael Droste
  • Function : Author
Judith Hey-Hadavi
  • Function : Author
Christian J. Strasburger
  • Function : Author
Cecilia Camacho-Hubner
  • Function : Author

Abstract

PurposeTo explore the effects of pegvisomant (PEGV) on glucose metabolism in patients with acromegaly within ACROSTUDY, an international, observational, prospective safety surveillance study.MethodsPatients were retrospectively divided into two cohorts, with (DM group) or without diabetes mellitus (no-DM). Parameters of glucose metabolism and IGF-I values were analyzed yearly both cross-sectionally for 4 years (yrs) and longitudinally at 1 and 4-5yrs of PEGV treatment.ResultsAmong 1762 patients, 510 (28.9%) had DM before PEGV start. At cross-sectional analyses, in the DM group mean blood glucose was 140.058.7mg/dl at baseline, 116.4 +/- 44.8mg/dl at year 1 and 120.0 +/- 44.3mg/dl at yr 4. Mean HbA1c was 6.6 +/- 1.2 % at yr 1 vs. 7.0 +/- 1.4 % at baseline. HbA1c was above 6.5% in 61.9% at baseline and ranged from 45.4 to 53.8% at subsequent yearly time points. At the 4-yr longitudinal analysis, in the DM group (n=109), mean blood glucose decreased by 20.2mg/dl at yr 4, mean HbA1c was 7.0 +/- 1.5% at baseline vs. 6.8 +/- 1.4%. Patients achieved IGF-I normalization in 52.1% and 57.4% of cases in the DM and no-DM groups, respectively at 1 year. The mean daily PEGV dose (mg/day) was higher in the DM group (18.2 vs. 15.3) while the absolute change of IGF-I values from baseline was similar in both groups. PEGV was well tolerated in both groups without any unexpected AEs.Conclusions p id=Par4 Patients with DM had a moderate decrease in mean fasting glucose values during PEGV treatment.

Domains

Genetics

Dates and versions

hal-02461466 , version 1 (30-01-2020)

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Cite

Thierry Brue, Anders Lindberg, Aart Jan van Der Lely, Ann Charlotte Akerblad, Maria Koltowska-Haeggstrom, et al.. Diabetes in patients with acromegaly treated with pegvisomant: observations from acrostudy. Endocrine, 2019, 63 (3), pp.563-572. ⟨10.1007/s12020-018-1792-0⟩. ⟨hal-02461466⟩

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