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Journal Articles Open Forum Infectious Diseases Year : 2020

Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

Abstract

Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV-bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV-bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30-6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.
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hal-03149230 , version 1 (05-07-2023)

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Attribution - NonCommercial - NoDerivatives

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Raphael Godefroy, Audrey Giraud-Gatineau, Marie-Therese Jimeno, Sophie Edouard, Line Meddeb, et al.. Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults. Open Forum Infectious Diseases, 2020, 7 (12), ⟨10.1093/ofid/ofaa546⟩. ⟨hal-03149230⟩
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