Exacerbation of circadian rhythms of core body temperature and sepsis in trauma patients - Aix-Marseille Université Access content directly
Journal Articles Journal of Critical Care Year : 2020

Exacerbation of circadian rhythms of core body temperature and sepsis in trauma patients

Abstract

Purpose: This study aimed to describe by mathematical modeling an accurate course of core body temperature (CBT) in severe trauma patients and its relation to sepsis. Methods: In a cohort of severe trauma, the CBT measurements were collected for 24 h on day 2 after admission and rhythmicity assessed by Fourier transform and Cosinor analysis to describe circadian features (frequency and amplitude). CBT was compared between patients who developed sepsis or not during the early ICU stay. Results: 33 patients were included in this analysis. 24 patients (73%) had a predominant rhythm of 24 h (period). The main period was lower in the 9 remaining patients (6 of 12 h, 1 of 8 h, and 2 of 6 h). Other significant frequencies of oscillation (second and third frequencies) were found, which showed an association of several well marked rhythms. Patients with sepsis (n = 12) had a significantly higher level of CBT, but also more intense rhythms and higher amplitudes of CBT. Conclusion: Trauma patients exhibit complex temperature circadian rhythms. Early exacerbation of the temperature rhythmicity (in frequency and amplitude) is associated with the development of sepsis. This observation accentuates the concept of circadian disruption and sepsis in ICU patients. (C) 2020 Elsevier Inc. All rights reserved.
Fichier principal
Vignette du fichier
S0883944120306146.pdf (2.7 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03149237 , version 1 (22-08-2022)

Licence

Attribution - NonCommercial

Identifiers

Cite

Benjamin Coiffard, Aissatou B. Diallo, Aurelien Culver, Francois Antonini, Emmanuelle Hammad, et al.. Exacerbation of circadian rhythms of core body temperature and sepsis in trauma patients. Journal of Critical Care, 2020, 60, pp.23-26. ⟨10.1016/j.jcrc.2020.07.010⟩. ⟨hal-03149237⟩

Collections

IRD CNRS UNIV-AMU
24 View
6 Download

Altmetric

Share

Gmail Facebook X LinkedIn More