Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains - Aix-Marseille Université Access content directly
Journal Articles Scientific Reports Year : 2020

Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains

Beatrice Comte
  • Function : Author
Stephanie Joubert
  • Function : Author
Philippe Seyral
  • Function : Author
Christophe Maruejouls
  • Function : Author
Jean-Christophe Achiardy
  • Function : Author
Sophie Burignat
  • Function : Author
Joseph Carvajal
  • Function : Author
Edouard Delaunay
  • Function : Author
Sandra Meyer
  • Function : Author
Patricia Roussellier
  • Function : Author
Patrick Brunet
  • Function : Author
Claude Bosi
  • Function : Author
Philippe Stolidi
  • Function : Author
Jean-Pierre Arzouni
  • Function : Author
Gisele Gay
  • Function : Author
Pierre Hance
  • Function : Author

Abstract

The burden of antibiotic resistance is currently estimated by mathematical modeling, without real count of resistance to key antibiotics. Here we report the real rate of resistance to key antibiotics in bacteria isolated from humans during a 5 years period in a large area in southeast in France. We conducted a retrospective study on antibiotic susceptibility of 539,107 clinical strains isolated from hospital and private laboratories in south of France area from January 2014 to January 2019. The resistance rate to key antibiotics as well as the proportion of bacteria classified as Difficult-to-Treat (DTR) were determined and compared with the Mann-Whitney U test, the chi(2) test or the Fisher's exact test. Among 539,037 isolates, we did not observe any significant increase or decrease in resistance to key antibiotics for 5 years, (oxacillin resistance in Staphylococcus aureus, carbapenem resistance in enterobacteria and Pseudomonas aeruginosa and 3rd generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae). However, we observed a significant decrease in imipenem resistance for Acinetobacter baumannii from 2014 to 2018 (24.19-12.27%; p = 0.005) and a significant increase of ceftriaxone resistance in Klebsiella pneumoniae (9.9-24.03%; p = 0.001) and Enterobacter cloacae (24.05-42.05%; p = 0.004). Of these 539,037 isolates, 1604 (0.3%) had a DTR phenotype. Over a 5-year period, we did not observe a burden of AR in our region despite a high rate of antibiotic consumption in our country. These results highlight the need for implementation of real-time AR surveillance systems which use factual data.

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hal-03149270 , version 1 (28-09-2023)

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Ousmane Oumou Diallo, Sophie Alexandra Baron, Gregory Dubourg, Herve Chaudet, Philippe Halfon, et al.. Major discrepancy between factual antibiotic resistance and consumption in South of France: analysis of 539,037 bacterial strains. Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-75158-7⟩. ⟨hal-03149270⟩
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