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Journal Articles Journal of Infectious Diseases Year : 2020

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

Laurent Arnaud
Marie Koubi

Abstract

Beside the commonly described pulmonary expression of the coronavirus disease 2019 (COVID-19), major vascular events have been reported. The objective of this study was to investigate whether increased levels of circulating endothelial cells (CECs) might be associated with severe forms of COVID-19. Ninety-nine patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher CEC counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. Together, these data provide in vivo evidence that endothelial injury is a key feature of COVID-19.
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hal-03171102 , version 1 (16-03-2021)

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Christophe Guervilly, Stéphane Burtey, Florence Sabatier, Raphaël Cauchois, Guillaume Lano, et al.. Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19. Journal of Infectious Diseases, 2020, 222 (11), pp.1789-1793. ⟨10.1093/infdis/jiaa528⟩. ⟨hal-03171102⟩
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