The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells - Aix-Marseille Université Access content directly
Journal Articles Journal of Infectious Diseases Year : 2020

The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells

Yu-Min Chuang
Tolulope Agunbiade
  • Function : Author
Xu-Dong Tang
  • Function : Author
Marianna Freudzon
  • Function : Author
Erol Fikrig
  • Function : Author

Abstract

Abstract Malaria begins when Plasmodium-infected Anopheles mosquitoes take a blood meal on a vertebrate. During the initial probing process, mosquitoes inject saliva and sporozoites into the host skin. Components of mosquito saliva have the potential to influence sporozoite functionality. Sporozoite-associated mosquito saliva protein 1 (SAMSP1; AGAP013726) was among several proteins identified when sporozoites were isolated from saliva, suggesting it may have an effect on Plasmodium. Recombinant SAMSP1 enhanced sporozoite gliding and cell traversal activity in vitro. Moreover, SAMSP1 decreased neutrophil chemotaxis in vivo and in vitro, thereby also exerting an influence on the host environment in which the sporozoites reside. Active or passive immunization of mice with SAMSP1 or SAMSP1 antiserum diminished the initial Plasmodium burden after infection. Passive immunization of mice with SAMSP1 antiserum also added to the protective effect of a circumsporozoite protein monoclonal antibody. SAMSP1 is, therefore, a mosquito saliva protein that can influence sporozoite infectivity in the vertebrate host.

Dates and versions

hal-03211362 , version 1 (28-04-2021)

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Cite

Yu-Min Chuang, Tolulope Agunbiade, Xu-Dong Tang, Marianna Freudzon, Lionel Almeras, et al.. The Effects of A Mosquito Salivary Protein on Sporozoite Traversal of Host Cells. Journal of Infectious Diseases, 2020, ⟨10.1093/infdis/jiaa759⟩. ⟨hal-03211362⟩

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