Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal. - Aix-Marseille Université Access content directly
Journal Articles International Journal of Environmental Research and Public Health Year : 2021

Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal.

Abstract

In central Senegal, malaria incidence declined in response to scaling-up of control measures from 2000 to 2010 and has since remained stable, making elimination unlikely in the short term. Additional control measures are needed to reduce transmission. We simulated chemoprophylaxis interventions targeting malaria hotspots using a metapopulation mathematical model, based on a differential-equation framework and incorporating human mobility. The model was fitted to weekly malaria incidence from 45 villages. Three approaches for selecting intervention targets were compared: (a) villages with malaria cases during the low transmission season of the previous year; (b) villages with highest incidence during the high transmission season of the previous year; (c) villages with highest connectivity with adjacent populations. Our results showed that intervention strategies targeting hotspots would be effective in reducing malaria incidence in both targeted and untargeted areas. Regardless of the intervention strategy used, pre-elimination (1-5 cases per 1000 per year) would not be reached without simultaneously increasing vector control by more than 10%. A cornerstone of malaria control and elimination is the effective targeting of strategic locations. Mathematical tools help to identify those locations and estimate the impact in silico.
Fichier principal
Vignette du fichier
ijerph-18-00076.pdf (5.22 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03215999 , version 1 (21-06-2023)

Identifiers

Cite

Kankoé Sallah, Roch Giorgi, El-Hadj Ba, Martine Piarroux, Renaud Piarroux, et al.. Targeting Malaria Hotspots to Reduce Transmission Incidence in Senegal.. International Journal of Environmental Research and Public Health, 2021, 18 (1), pp.76. ⟨10.3390/ijerph18010076⟩. ⟨hal-03215999⟩
81 View
16 Download

Altmetric

Share

Gmail Facebook X LinkedIn More