Genetics of neonatal onset epilepsies: An overview - Aix-Marseille Université Access content directly
Journal Articles Revue Neurologique Year : 2020

Genetics of neonatal onset epilepsies: An overview

Abstract

The weight of monogenic abnormalities in the possible causes of epilepsy has grown significantly in recent years, due to the emergence of next-generation sequencing (NGS) techniques. Especially notable in early neonatal and infantile epilepsies, which seem to be explained by monogenic abnormalities. This short review focuses on the major genes associated with very early-onset epilepsies, where NGS techniques are most cost-effective: early infantile epileptic encephalopathy, early myoclonic encephalopathy, and other neonatal epilepsies. The discovery of the genetic mutation often follows several weeks or months of management, and rarely modifies it. However, clinical studies can sometimes better define medical treatment. The genetic causes of these epilepsies are very numerous and the pathophysiological knowledge very minimal. The big challenge for the coming years is to develop more targeted treatments based on research on animal models.
Fichier principal
Vignette du fichier
Genetics-of-neonatal-onset-epilepsies_Milh-2020-.pdf (1.61 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03222897 , version 1 (11-05-2021)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Mathieu Milh, Florence Riccardi, J. Denis. Genetics of neonatal onset epilepsies: An overview. Revue Neurologique, 2020, 176 (1-2), pp.2-9. ⟨10.1016/j.neurol.2019.01.396⟩. ⟨hal-03222897⟩

Collections

UNIV-AMU MMG
33 View
237 Download

Altmetric

Share

Gmail Facebook X LinkedIn More