Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols - Aix-Marseille Université Access content directly
Journal Articles Journal of Organic Chemistry Year : 2020

Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols

Abstract

We report here the intermolecular metal-free addition reaction of functionalized benzyl halides to aldehydes using a super electron donor (SED). The metal-free and mild conditions allowed the formation of 3,4-dihydroisocoumarins and 1,2diarylethanols with unprecedented functional group tolerance.
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Dates and versions

hal-03254096 , version 1 (08-06-2021)

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Cédric Spitz, Mélanie Matteudi, Guillaume Tintori, Julie Broggi, Thierry Terme, et al.. Metal-Free Addition of Benzyl Halides to Aldehydes Using Super Electron Donors: Access to 3,4-Dihydroisocoumarins and 1,2-Diarylethanols. Journal of Organic Chemistry, 2020, 85 (23), pp.15736-15742. ⟨10.1021/acs.joc.0c02374⟩. ⟨hal-03254096⟩
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