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Journal Articles Year : 2021

Antimicrobial Peptides: A Potent Alternative to Antibiotics

Mohamad Rima
Ziad Fajloun
Jean-Marc Sabatier
Burkhard Bechinger
Thierry Naas


Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. This review focuses on their use against ESKAPE bacteria, especially in biofilm treatments, their synergistic activity, and their application as prophylactic agents. Limitations and challenges restricting therapeutic applications are highlighted, and solutions for each challenge are evaluated to analyze whether antimicrobial peptides could replace antibiotics in the near future.
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Dates and versions

hal-03357922 , version 1 (07-03-2022)





Mariam Rima, Mohamad Rima, Ziad Fajloun, Jean-Marc Sabatier, Burkhard Bechinger, et al.. Antimicrobial Peptides: A Potent Alternative to Antibiotics. 2021, 10 (9), pp.1095. ⟨10.3390/antibiotics10091095⟩. ⟨hal-03357922⟩
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