Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge - Aix-Marseille Université Access content directly
Journal Articles Genes Year : 2021

Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge

Abstract

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to morphology, immunophenotyping, germline and somatic cytogenetic and genetic abnormalities. Over recent decades, outcomes have greatly improved, although survival rates remain around 70% and the relapse rate is high, at around 30%. Cytogenetics is an important factor for diagnosis and indication of prognosis. The main cytogenetic abnormalities are referenced in the current WHO classification of acute myeloid leukemia, where there is an indication for risk-adapted therapy. The aim of this article is to provide an updated review of cytogenetics in pediatric AML, describing well-known WHO entities, as well as new subgroups and germline mutations with therapeutic implications. We describe the main chromosomal abnormalities, their frequency according to age and AML subtypes, and their prognostic relevance within current therapeutic protocols. We focus on de novo AML and on cytogenetic diagnosis, including the practical difficulties encountered, based on the most recent hematological and cytogenetic recommendations.
Fichier principal
Vignette du fichier
genes-12-00924.pdf (1.21 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-03374740 , version 1 (27-06-2023)

Licence

Attribution

Identifiers

Cite

Julie Quessada, Wendy Cuccuini, Paul Saultier, Marie Loosveld, Christine Harrison, et al.. Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge. Genes, 2021, 12 (6), pp.924. ⟨10.3390/genes12060924⟩. ⟨hal-03374740⟩
27 View
32 Download

Altmetric

Share

Gmail Facebook X LinkedIn More