Numerical modeling of residual type B aortic dissection: longitudinal analysis of favorable and unfavorable evolution - Aix-Marseille Université Access content directly
Journal Articles Medical and Biological Engineering and Computing Year : 2022

Numerical modeling of residual type B aortic dissection: longitudinal analysis of favorable and unfavorable evolution

Abstract

Residual type B aortic dissection was numerically investigated to highlight the contribution of biomechanical parameters to the pathology's evolution. Patient-specific geometries from cases involving both favorable and unfavorable evolution were modeled to assess their hemodynamic features. This original approach was supported by a longitudinal study confirming the association between morphological changes, hemodynamic features, adverse clinical outcomes, and CT-angioscan observations on the same patient. Comparing one patient with unfavorable evolution with one with favorable one, we identify potential biomechanical indicators predictive of unfavorable evolution: (i) a patent false lumen with a flow rate above 50% of inlet flow rate; (ii) high wall shear stress above 18 Pa at entry tears, and above 10 Pa at some regions of the false lumen wall; (iii) low time-averaged wall shear stress in distal false lumen below 0.5 Pa; (iv) vortical structure dynamics. Although these comparisons could only be conducted on 2 patients and need to be confirmed by a larger number of cases, our findings point to these hemodynamic markers as possible candidates for early evaluation of the pathology's evolution towards an unfavorable scenario.
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Dates and versions

hal-03544285 , version 1 (21-11-2022)

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Khannous Fatma, Guivier-Curien Carine, Gaudry Marine, Piquet Philippe, Valerie Deplano. Numerical modeling of residual type B aortic dissection: longitudinal analysis of favorable and unfavorable evolution. Medical and Biological Engineering and Computing, 2022, ⟨10.1007/s11517-021-02480-1⟩. ⟨hal-03544285⟩
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