Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France - Aix-Marseille Université Access content directly
Journal Articles Archives of Virology Year : 2022

Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France

Abstract

We detected SARS-CoV-2 of PANGO lineage R.1 with the spike substitution E484K in three patients. Eleven other sequences in France and 8,831 worldwide were available from GISAID, 92% originating from Japan. The three genome sequences from our institute were phylogenetically closest to another from Guinea-Conakry, where one of the patients had travelled. These viruses did not exhibit any unusual features in cell culture. Spike structural predictions indicated a 1.3-time higher transmissibility index than for the globally spread B.1.1.7 variant but also an affinity loss for gangliosides that might have slowed dissemination. The spread of new SARS-CoV-2 mutants/variants is still not well understood and therefore difficult to predict, and this hinders implementation of effective preventive measures, including adapted vaccines.

Dates and versions

hal-03663685 , version 1 (05-10-2023)

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Cite

Philippe Colson, Jacques Fantini, Nouara Yahi, Jeremy Delerce, Anthony Levasseur, et al.. Limited spread of a rare spike E484K-harboring SARS-CoV-2 in Marseille, France. Archives of Virology, 2022, 167 (2), pp.583-589. ⟨10.1007/s00705-021-05331-4⟩. ⟨hal-03663685⟩
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