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Journal Articles Journal of Fungi Year : 2021

MixInYeast: A Multicenter Study on Mixed Yeast Infections

Narda Medina
  • Function : Author
Juan Soto-Debrán
  • Function : Author
Danila Seidel
  • Function : Author
Isin Akyar
  • Function : Author
Hamid Badali
Aleksandra Barac
Carmen Castro
  • Function : Author
Eric Dannaoui
Celia Cardozo
  • Function : Author
Julio Garcia-Rodriguez
  • Function : Author
Juliette Guitard
Petr Hamal
Sadegh Khodavaisy
Giuliana Lo Cascio
  • Function : Author
María Martínez-Rubio
  • Function : Author
Joseph Meletiadis
Patricia Muñoz
  • Function : Author
Elżbieta Ochman
  • Function : Author
Teresa Peláez
  • Function : Author
Ana Perez-Ayala Balzola
  • Function : Author
Juergen Prattes
Emmanuel Roilides
Maite Ruíz-Pérez de Pipaón
  • Function : Author
Raphael Stauf
  • Function : Author
Jörg Steinmann
  • Function : Author
Ana Suárez-Barrenechea
  • Function : Author
Rocío Tejero
  • Function : Author
Laura Trovato
  • Function : Author
Lourdes Viñuela
Thanwa Wongsuk
  • Function : Author
Iwona Żak
  • Function : Author
Hossein Zarrinfar
Cornelia Lass-Flörl
Sevtap Arikan-Akdagli
  • Function : Author
Ana Alastruey-Izquierdo


Invasive candidiasis remains one of the most prevalent systemic mycoses, and several studies have documented the presence of mixed yeast (MY) infections. Here, we describe the epidemiology, clinical, and microbiological characteristics of MY infections causing invasive candidiasis in a multicenter prospective study. Thirty-four centers from 14 countries participated. Samples were collected in each center between April to September 2018, and they were sent to a reference center to confirm identification by sequencing methods and to perform antifungal susceptibility testing, according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST). A total of 6895 yeast cultures were identified and MY occurred in 150 cases (2.2%). Europe accounted for the highest number of centers, with an overall MY rate of 4.2% (118 out of 2840 yeast cultures). Of 122 MY cases, the most frequent combinations were Candida albicans/C. glabrata (42, 34.4%), C. albicans/C. parapsilosis (17, 14%), and C. glabrata/C. tropicalis (8, 6.5%). All Candida isolates were susceptible to amphotericin B, 6.4% were fluconazole-resistant, and two isolates (1.6%) were echinocandin-resistant. Accurate identification of the species involved in MY infections is essential to guide treatment decisions.
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Dates and versions

hal-03666341 , version 1 (07-07-2023)





Narda Medina, Juan Soto-Debrán, Danila Seidel, Isin Akyar, Hamid Badali, et al.. MixInYeast: A Multicenter Study on Mixed Yeast Infections. Journal of Fungi, 2021, 7 (1), pp.13. ⟨10.3390/jof7010013⟩. ⟨hal-03666341⟩
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