Grey-matter sodium concentration as an individual marker of multiple sclerosis severity
Résumé
Objective: Quantification of brain injury in patients with variable disability despite similar disease duration may be relevant to identify the mechanisms underlying disability in MS. We aimed to compare grey-matter sodium abnormalities (GMSA), a parameter reflecting neuronal and astrocyte dysfunction, in MS patients with benign MS (BMS) and non-benign MS (NBMS). Methods: We identified never-treated BMS patients in our local MS database of 1352 patients. A group with NBMS was identified with same disease duration. All participants underwent 23 Na MRI. The existence of GMSA was detected by statistical analysis. Results: In total, 102 individuals were included (21 BMS, 25 NBMS and 56 controls). GMSA was detected in 10 BMS and 19 NBMS (11/16 RRMS and 8/9 SPMS) patients (p=0.05). On logistic regression including the presence or absence of GMSA, thalamic volume, cortical grey matter volume and T2-weighted lesion load, thalamic volume was independently associated with BMS status (OR=0.64 for each unit). Nonetheless, the absence of GMSA was independently associated when excluding patients with significant cognitive alteration (n=7) from the BMS group (OR=4.6). Conclusion: Detection of GMSA in individuals and thalamic volume are promising to differentiate BMS from NBMS as compared with cortical or whole grey-matter atrophy and T2-weighted lesions.
Domaines
Neurosciences [q-bio.NC]| Origine | Fichiers produits par l'(les) auteur(s) |
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