Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19 - Aix-Marseille Université Access content directly
Journal Articles Scientific Reports Year : 2022

Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19

Abstract

Whereas the detection of antiphospholipid autoantibodies (aPL) in COVID-19 is of increasing interest, their role is still unclear. We analyzed a large aPL panel in 157 patients with COVID-19 according to the disease severity. We also investigated a potential association between aPL and extracellular DNA (exDNA, n = 85) or circulating markers of neutrophil extracellular traps (NET) such as citrullinated histones H3 (CitH3, n = 49). A total of 157 sera of patients infected by SARS-CoV-2 were collected. A large aPL panel including lupus anticoagulant, anti-cardiolipin and anti-beta-2 glycoprotein I (IgG, IgM and IgA), anti-phosphatidylethanolamine IgA, anti-prothrombin (IgG and IgM) was retrospectively analyzed according to the disease severity. We found a total aPL prevalence of 54.8% with almost half of the cases having aCL IgG. Within an extended panel of aPL, only aCL IgG were associated with COVID-19 severity. Additionally, severe patients displayed higher CitH3 levels than mild patients. Interestingly, we highlighted a significant association between the levels of aCL IgG and exDNA only in aCL positive patients with severe disease. In conclusion, we showed a significant link between aPL, namely aCL IgG, and circulating exDNA in patients with severe form of COVID-19, that could exacerbate the thrombo-inflammatory state related to disease severity.
Fichier principal
Vignette du fichier
s41598-022-15969-y.pdf (1.39 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Licence : CC BY - Attribution

Dates and versions

hal-03792013 , version 1 (06-09-2023)

Licence

Attribution

Identifiers

Cite

Daniel Bertin, Alexandre Brodovitch, Alexandre Lopez, Robin Arcani, Grace Thomas, et al.. Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19. Scientific Reports, 2022, 12 (1), pp.12523. ⟨10.1038/s41598-022-15969-y⟩. ⟨hal-03792013⟩
36 View
7 Download

Altmetric

Share

Gmail Facebook X LinkedIn More