Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle - Aix-Marseille Université Access content directly
Journal Articles Pflügers Archiv European Journal of Physiology Year : 2021

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle

Medical image segmentation automatic quality control: A multi-dimensional approach

Jae Mo Park
Sonal Josan
  • Function : Author
Ralph Hurd
  • Function : Author
James Graham
  • Function : Author
Peter Havel
  • Function : Author
Dirk Mayer
  • Function : Author
Youngran Chung
  • Function : Author
Daniel Spielman
  • Function : Author
Thomas Jue

Abstract

The main finding of the present study was that the metabolic changes associated with a moderate-intensity muscle exercise were slightly modified in stable sickle cell anemia patients and sickle cell trait carriers as compared to controls but still in the normal range. The present results strongly support the safety of a moderate-intensity exercise for stable sickle cell anemia patients and sickle cell trait carriers.

Dates and versions

hal-03818772 , version 1 (09-01-2024)

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Jae Mo Park, Sonal Josan, Ralph Hurd, James Graham, Peter Havel, et al.. Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle. Pflügers Archiv European Journal of Physiology, 2021, 473 (11), pp.1761-1773. ⟨10.1007/s00424-021-02613-3⟩. ⟨hal-03818772⟩
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