A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2022

A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review

Résumé

Whipple’s disease (WD) is a chronic multisystemic infection caused by Tropheryma whipplei . If this bacterium presents an intracellular localization, associated with rare diseases and without pathognomonic signs, it is often subject to a misunderstanding of its physiopathology, often a misdiagnosis or simply an oversight. Here, we report the case of a patient treated for presumed rheumatoid arthritis. Recently, this patient presented to the hospital with infectious endocarditis. After surgery and histological analysis, we discovered the presence of T. whipplei . Electron microscopy allowed us to discover an atypical bacterial organization with a very large number of bacteria present in the extracellular medium in vegetation and valvular tissue. This atypical presentation we report here might be explained by the anti-inflammatory treatment administrated for our patient’s initial diagnosis of rheumatoid arthritis.
Fichier principal
Vignette du fichier
fimmu-13-900589.pdf (1.05 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-03823867 , version 1 (29-05-2024)

Licence

Identifiants

Citer

Nadji Hannachi, Florent Arregle, Hubert Lepidi, Jean-Pierre Baudoin, Frédérique Gouriet, et al.. A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review. Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.900589⟩. ⟨hal-03823867⟩

Collections

IRD CNRS UNIV-AMU
35 Consultations
5 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More