A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review - Aix-Marseille Université Access content directly
Journal Articles Frontiers in Immunology Year : 2022

A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review

Abstract

Whipple’s disease (WD) is a chronic multisystemic infection caused by Tropheryma whipplei . If this bacterium presents an intracellular localization, associated with rare diseases and without pathognomonic signs, it is often subject to a misunderstanding of its physiopathology, often a misdiagnosis or simply an oversight. Here, we report the case of a patient treated for presumed rheumatoid arthritis. Recently, this patient presented to the hospital with infectious endocarditis. After surgery and histological analysis, we discovered the presence of T. whipplei . Electron microscopy allowed us to discover an atypical bacterial organization with a very large number of bacteria present in the extracellular medium in vegetation and valvular tissue. This atypical presentation we report here might be explained by the anti-inflammatory treatment administrated for our patient’s initial diagnosis of rheumatoid arthritis.

Dates and versions

hal-03823867 , version 1 (21-10-2022)

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Nadji Hannachi, Florent Arregle, Hubert Lepidi, Jean-Pierre Baudoin, Frédérique Gouriet, et al.. A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review. Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.900589⟩. ⟨hal-03823867⟩

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