The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication - Aix-Marseille Université Access content directly
Journal Articles Journal of Virology Year : 2022

The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication

Abstract

Replicating large genomes represents a challenge for RNA viruses because fast RNA synthesis is needed to escape innate immunity defenses, but faster polymerases are inherently low-fidelity enzymes. Nonetheless, the coronaviruses replicate their ≈30-kb genomes using the core polymerase structure and mechanism common to all positive-strand RNA viruses.

Dates and versions

hal-03937362 , version 1 (13-01-2023)

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Grace Campagnola, Vishnu Govindarajan, Annelise Pelletier, Bruno Canard, Olve Peersen. The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication. Journal of Virology, 2022, 96 (16), ⟨10.1128/jvi.00671-22⟩. ⟨hal-03937362⟩
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