Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells - Aix-Marseille Université Access content directly
Journal Articles Molecular Biology of the Cell Year : 2022

Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells

Carl-Gustaf Stenvall
  • Function : Author
Joel Nyström
  • Function : Author
Theresia Jansson
  • Function : Author
Taina Heikkilä
  • Function : Author
Stephen Adam
  • Function : Author
Roland Foisner
  • Function : Author
Robert Goldman
  • Function : Author
Karen Ridge
  • Function : Author
Diana Toivola
  • Function : Author

Abstract

Cytoplasmic keratins couple with SUN2 and lamin A at the nuclear envelope and maintain plectin, LINC complex, lamin and lamin-associated protein levels in colonic epithelial cells. Loss of keratin 8 has no major impact on nuclear shape and size, but compromises nuclear envelope integrity basally and during shear stress.

Dates and versions

hal-03982203 , version 1 (10-02-2023)

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Carl-Gustaf Stenvall, Joel Nyström, Ciarán Butler-Hallissey, Theresia Jansson, Taina Heikkilä, et al.. Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells. Molecular Biology of the Cell, 2022, 33 (13), pp.ar121. ⟨10.1091/mbc.E20-06-0387⟩. ⟨hal-03982203⟩
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