Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study - Aix-Marseille Université Access content directly
Journal Articles Oncologist Year : 2022

Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

Louis Garnier
Chrystelle Vidal
  • Function : Author
Olivier Chinot
  • Function : Author
Elisabeth Cohen-Jonathan Moyal
  • Function : Author
Apolline Djelad
  • Function : Author
Charlotte Bronnimann
  • Function : Author
Lien Bekaert
  • Function : Author
Luc Taillandier
  • Function : Author
Jean-Sébastien Frenel
  • Function : Author
Olivier Langlois
  • Function : Author
Philippe Colin
  • Function : Author
Philippe Menei
  • Function : Author
Frédéric Dhermain
  • Function : Author
Catherine Carpentier
  • Function : Author
Aurélie Gerazime
  • Function : Author
Elsa Curtit
  • Function : Author
Caroline Dehais
  • Function : Author
François Ducray
  • Function : Author

Abstract

Background Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics. Methods We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network. Results Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatment, STS less frequently underwent a surgical resection than CS (P = .= .0001) and were more frequently treated with chemotherapy alone (P = .= .009) or with radiotherapy plus temozolomide (P = .= .05). Characteristics independently associated with STS in multivariate analysis were cognitive dysfunction, a number of mitosis > 8, and the absence of tumor resection. Based on cognitive dysfunction, type of surgery, and number of mitosis, patients could be classified into groups of standard (18%) and high (62%) risk of <5 year survival. Conclusion The present study suggests that although STS poor outcome appears to largely result from a more advanced disease at diagnosis, surgical resection may be particularly important in this population.
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hal-03982381 , version 1 (04-07-2023)

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Louis Garnier, Chrystelle Vidal, Olivier Chinot, Elisabeth Cohen-Jonathan Moyal, Apolline Djelad, et al.. Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study. Oncologist, 2022, 27 (5), pp.414-423. ⟨10.1093/oncolo/oyac023⟩. ⟨hal-03982381⟩
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