Molecular Basis and Natural History of Medullary Thyroid Cancer: It is (Almost) All in the RET
Résumé
Medullary thyroid carcinoma (MTC) is a rare neoplasm supported by a strong genetic determinism. This review summarizes the genetic landscape of MTC at both germline and somatic levels to understand the molecular basis and the natural history of the tumour, mainly but not exclusively, linked to RET proto-oncogene genetic abnormalities. RET is a tyrosine kinase receptor that represents a therapeutic target with encouraging results. However, some RET genetic variations could lead to treatment resistance.
Origine | Fichiers éditeurs autorisés sur une archive ouverte |
---|---|
Licence |