Cytological Diagnosis of Classic Myeloproliferative Neoplasms at the Age of Molecular Biology - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Cells Année : 2023

Cytological Diagnosis of Classic Myeloproliferative Neoplasms at the Age of Molecular Biology

Résumé

Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell-derived disorders characterized by uncontrolled proliferation of differentiated myeloid cells. Two main groups of MPN, BCR::ABL1-positive (Chronic Myeloid Leukemia) and BCR::ABL1-negative (Polycythemia Vera, Essential Thrombocytosis, Primary Myelofibrosis) are distinguished. For many years, cytomorphologic and histologic features were the only proof of MPN and attempted to distinguish the different entities of the subgroup BCR::ABL1-negative MPN. World Health Organization (WHO) classification of myeloid neoplasms evolves over the years and increasingly considers molecular abnormalities to prove the clonal hematopoiesis. In addition to morphological clues, the detection of JAK2, MPL and CALR mutations are considered driver events belonging to the major diagnostic criteria of BCR::ABL1-negative MPN. This highlights the preponderant place of molecular features in the MPN diagnosis. Moreover, the advent of next-generation sequencing (NGS) allowed the identification of additional somatic mutations involved in clonal hematopoiesis and playing a role in the prognosis of MPN. Nowadays, careful cytomorphology and molecular biology are inseparable and complementary to provide a specific diagnosis and to permit the best follow-up of these diseases.
Fichier principal
Vignette du fichier
cells-12-00946.pdf (4.75 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04236711 , version 1 (11-10-2023)

Licence

Paternité

Identifiants

Citer

Sophie Combaluzier, Julie Quessada, Norman Abbou, Robin Arcani, Antoine Tichadou, et al.. Cytological Diagnosis of Classic Myeloproliferative Neoplasms at the Age of Molecular Biology. Cells, 2023, 12 (6), pp.946. ⟨10.3390/cells12060946⟩. ⟨hal-04236711⟩
16 Consultations
10 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More