Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response - Aix-Marseille Université Access content directly
Journal Articles Frontiers in Immunology Year : 2023

Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response

Abstract

Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization.
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hal-04279278 , version 1 (16-02-2024)

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Christian Devaux, Jacques Fantini. Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response. Frontiers in Immunology, 2023, 14, ⟨10.3389/fimmu.2023.1252367⟩. ⟨hal-04279278⟩
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