Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Pharmaceutics Année : 2023

Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes

Résumé

Plasmonic nanoparticles (NP) possess great potential in photothermal therapy and diagnostics. However, novel NP require a detailed examination for potential toxicity and peculiarities of interaction with cells. Red blood cells (RBC) are important for NP distribution and the development of hybrid RBC-NP delivery systems. This research explored RBC alterations induced by noble (Au and Ag) and nitride-based (TiN and ZrN) laser-synthesized plasmonic NP. Optical tweezers and conventional microscopy modalities indicated the effects arising at non-hemolytic levels, such as RBC poikilocytosis, and alterations in RBC microrheological parameters, elasticity and intercellular interactions. Aggregation and deformability significantly decreased for echinocytes independently of NP type, while for intact RBC, all NP except Ag NP increased the interaction forces but had no effect on RBC deformability. RBC poikilocytosis promoted by NP at concentration 50 µg mL −1 was more pronounced for Au and Ag NP, compared to TiN and ZrN NP. Nitride-based NP demonstrated better biocompatibility towards RBC and higher photothermal efficiency than their noble metal counterparts.
Fichier principal
Vignette du fichier
pharmaceutics-PlasmonicNPsErythrocytes.pdf (77.96 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04303583 , version 1 (23-11-2023)

Licence

Paternité

Identifiants

Citer

Tatiana Avsievich, Ruixue Zhu, Alexey P Popov, Alexander Yatskovskiy, Anton A Popov, et al.. Impact of Plasmonic Nanoparticles on Poikilocytosis and Microrheological Properties of Erythrocytes. Pharmaceutics, 2023, 15 (4), pp.1046. ⟨10.3390/pharmaceutics15041046⟩. ⟨hal-04303583⟩
19 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More