Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae) - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2023

Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)

Gabrielle Amang À Ngnoung
  • Fonction : Auteur
Peron Leutcha
Yves Nganso Ditchou
Lauve Tchokouaha
  • Fonction : Auteur
Theodora Kowa
  • Fonction : Auteur
Desire Soh
  • Fonction : Auteur
Raoul Kemzeu
Madan Poka
Patrick Demana
  • Fonction : Auteur
Xavier Siwe Noundou
Alembert Tchinda
  • Fonction : Auteur
Fabrice Fekam Boyom
Alain Lannang
Barthélemy Nyassé
  • Fonction : Auteur

Résumé

Antrocaryon klaineanum is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from A. klaineanum. An unreported glucocerebroside antroklaicerebroside (1) together with five known compounds (2–6) were isolated from the root barks of Antrocaryon klaineanum using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds 1–4 are reported for the first time from A. klaineanum. The methanol crude extract (AK-MeOH), the n-hexane fraction (AK-Hex), the dichloromethane fraction (AK-DCM), the ethyl acetate fraction (AK-EtOAc), and compounds 1–6 were all evaluated for their antiparasitic effects against Plasmodium falciparum strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of Leishmania donovani (MHOM/SD/62/1S). The AK-Hex, AK-EtOAc, AK-MeOH, and compound 2 were strongly active against Dd2 strain with IC50 ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, AK-MeOH was the most active—more than the reference drugs used—with an IC50 of 2.78 ± 0.06 µg/mL. The AK-EtOAc as well as all the tested compounds showed strong antileishmanial activities with IC50 ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL.
Fichier principal
Vignette du fichier
molecules-28-02730-v2.pdf (1.47 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04447765 , version 1 (12-02-2024)

Licence

Paternité

Identifiants

Citer

Gabrielle Amang À Ngnoung, Lazare Sidjui, Peron Leutcha, Yves Nganso Ditchou, Lauve Tchokouaha, et al.. Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae). Molecules, 2023, 28 (6), pp.2730. ⟨10.3390/molecules28062730⟩. ⟨hal-04447765⟩
27 Consultations
7 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More