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Article Dans Une Revue Journal of Biochemical and Molecular Toxicology Année : 2023

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

Hayder Al-Kuraishy
  • Fonction : Auteur
Ali Al-Gareeb
  • Fonction : Auteur
Omayma Eldahshan
Yasmine Abdelkhalek
  • Fonction : Auteur
Magdy El Dahshan
  • Fonction : Auteur
Eman Ahmed
  • Fonction : Auteur
Jean-Marc Sabatier
Gaber E-S Batiha
  • Fonction : Auteur

Résumé

Abstract COVID‐19 is caused by a novel SARS‐CoV‐2 leading to pulmonary and extra‐pulmonary manifestations due to oxidative stress (OS) development and hyperinflammation. COVID‐19 is primarily asymptomatic though it may cause acute lung injury (ALI), acute respiratory distress syndrome (ARDS), systemic inflammation, and thrombotic events in severe cases. SARS‐CoV‐2‐induced OS triggers the activation of different signaling pathways, which counterbalances this complication. One of these pathways is nuclear factor erythroid 2‐related factor 2 (Nrf2), which induces a series of cellular interactions to mitigate SARS‐CoV‐2‐mediated viral toxicity and OS‐induced cellular injury. Nrf2 pathway inhibits the expression of pro‐inflammatory cytokines and the development of cytokine storm in COVID‐19. Therefore, Nrf2 activators may play an essential role in reducing SARS‐CoV‐2 infection‐induced inflammation by suppressing NLRP3 inflammasome in COVID‐19. Furthermore, Nrf2 activators can attenuate endothelial dysfunction (ED), renin‐angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Thus this mini‐review tries to clarify the possible role of the Nrf2 activators in the management of COVID‐19. Nrf2 activators could be an effective therapeutic strategy in the management of Covid‐19. Preclinical and clinical studies are recommended in this regard.
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Dates et versions

hal-04453071 , version 1 (12-02-2024)

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Hayder Al-Kuraishy, Ali Al-Gareeb, Omayma Eldahshan, Yasmine Abdelkhalek, Magdy El Dahshan, et al.. The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19. Journal of Biochemical and Molecular Toxicology, 2023, 38 (1), pp.e23605. ⟨10.1002/jbt.23605⟩. ⟨hal-04453071⟩
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