Risk factors associated with progression from papilloedema to optic atrophy: results from a cohort of 113 patients - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue BMJ Open Ophthalmology Année : 2023

Risk factors associated with progression from papilloedema to optic atrophy: results from a cohort of 113 patients

Résumé

The aim of this study was to assess the risk factors for atrophic progression of patients with papilloedema secondary to intracranial hypertension, using optical coherence tomography parameters. Methods A retrospective study was conducted at Marseille University Hospitals’ Ophthalmology departments between December 2015 and December 2021. All patients with papilloedema resulting from elevated intracranial hypertension at the initial presentation were included. Ophthalmological evaluations included analysing retinal nerve fibre layer (RNFL), ganglion cell layer (GCL) and total peripapillary retinal thickness (RT). Results The study included 222 eyes from 113 patients. The main aetiologies of intracranial hypertension were idiopathic intracranial hypertension (49/113), intracranial tumours (33/113) and cerebral venous thrombosis (15/113). The initial RNFL and RT showed significant correlations with optic atrophy. The mean RNFL was 199.63 µm in the ‘no atrophy’ group and 365.28 µm in the ‘atrophy’ group (p<0.001). Similarly, the mean RT was 483.72 µm in the ‘non-atrophy’ group and 796.69 µm in the ‘atrophy’ group (p<0.001). The presence of peripapillary haemorrhages showed a strong correlated with optic atrophy with an OR=19.12 (p<0.001). Impaired initial visual acuity was also associated with final optic atrophy with an OR=7.76 (p=0.020). Furthermore, impaired initial GCL was a major predictor of optic atrophy (OR=18.25 (p=0.021)). Conclusion Our study highlights the risk factors for optic atrophy in papilloedema, aiming to facilitate the early detection of patients at a high risk of vision loss and enable more aggressive medical or surgical management.
Fichier principal
Vignette du fichier
Attia-et-al-2023.pdf (538.74 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale

Dates et versions

hal-04556183 , version 1 (23-04-2024)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Ruben Attia, Ruben Fitoussi, Kevin Mairot, Sarah Demortiere, Jan-Patrick Stellman, et al.. Risk factors associated with progression from papilloedema to optic atrophy: results from a cohort of 113 patients. BMJ Open Ophthalmology, 2023, 8 (1), pp.e001375. ⟨10.1136/bmjophth-2023-001375⟩. ⟨hal-04556183⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More