Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group - Aix-Marseille Université
Article Dans Une Revue EJSO - European Journal of Surgical Oncology Année : 2024

Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group

Résumé

Objective: Vulvar cancer is a rare pathology affecting mainly elderly women. This study aims to evaluate the impact of age on tumor size in vulvar cancer. Material and methods: This was a multicenter retrospective observational study carried out between January 1, 1998, and December 31, 2020, in patients operated on for vulvar cancer. Univariate analysis was performed according to patients' age ≥ or <65 years. Factors associated with tumor size found to be significant according to age were then included in a multiple linear regression model. Results: Of the 382 patients included, there were 133 patients aged <65 years and 249 ≥ 65 years. Radical total vulvectomy surgeries were more frequently performed in women ≥65 years (n = 72 (28.9 %) versus n = 20 (15 %); p = 0.004). The median histological tumor size and interquartile range was 20 mm [13–29] in the <65 years and 30 mm [15–42] in patients ≥65 years (p = 0.001). Multiple linear regression showed that age ≥65 years had a regression coefficient of 7.15 95 % CI [2.32; 11.99] (p = 0.004), constituting a risk factor for larger histological tumour size. Patients aged ≥65 years old had a higher early complication rate (n = 150 (62 %) versus n = 56 (42.7 %), p = 0.001). They also had a greater risk of recurrence (HR = 1.89 (95%CI (1.24–2.89)), p = 0.003) with a worse overall survival (HR = 5.64 (95%CI (1.70–18.68)), p = 0.005). Conclusion: Age is a risk factor for larger tumor size, leading to more radical surgery and a greater risk of complications in already fragile patients, with a greater risk of recurrence and an impact on overall survival.

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Cancer
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Dates et versions

hal-04689357 , version 1 (03-10-2024)

Identifiants

Citer

E. Raimond, Y. Kerbage, L. Ouldamer, S. Bendifallah, Xavier Carcopino, et al.. Impact of age on tumor size in vulvar cancer: A multicenter study by the Francogyn group. EJSO - European Journal of Surgical Oncology, 2024, 50 (9), pp.108482. ⟨10.1016/j.ejso.2024.108482⟩. ⟨hal-04689357⟩
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