The Thymus-Specific Serine Protease TSSP/PRSS16 Is Crucial for the Antitumoral Role of CD4
Abstract
Graphical Abstract Highlights d TSSP is an important protease for intrathymic selection of CD4 + T cells d Absence of TSSP favors both spontaneous and inflammation-induced tumor development d TSSP-dependent maturation of CD4 + T cells in the thymus is required for tumor suppression d TSSP is a thymic protease with tumor suppressor activity
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