First Reported Chikungunya Fever Outbreak in the Republic of Congo, 2011 - Aix-Marseille Université Access content directly
Journal Articles PLoS ONE Year : 2014

First Reported Chikungunya Fever Outbreak in the Republic of Congo, 2011


Background: Chikungunya is an Aedes-borne disease characterised by febrile arthralgia and responsible for massive outbreaks. We present a prospective clinical cohort study and a retrospective serological study relating to a CHIK outbreak, in the Republic of Congo in 2011. Methodology and Findings: We analysed 317 suspected cases, of which 308 (97.2%) lived in the city of Brazzaville (66.6% in the South area). Amongst them, 37 (11.7%) were CHIKV+ve patients (i.e., biologically confirmed by a real-time RT-PCR assay), of whom 36 (97.3%) had fever, 22 (66.7%) myalgia and 32 (86.5%) arthralgia. All tested negative for dengue. The distribution of incident cases within Brazzaville districts was compared with CHIKV seroprevalence before the outbreak (34.4% in 517 blood donors), providing evidence for previous circulation of CHIKV. We applied a CHIK clinical score to 126 patients recruited within the two first day of illness (including 28 CHIKV+ves (22.2%)) with sensitivity (78.6%) and specificity (72.4%) values comparing with those of the referent study in Reunion Island. The negative predictive value was high (92%), but the positive predictive value (45%) indicate poor potential contribution to medical practice to identify CHIKV+ve patients in low prevalence outbreaks. However, the score allowed a slightly more accurate follow-up of the evolution of the outbreak than the criterion "fever+arthralgia". The complete sequencing of a Congolase isolate (Brazza_MRS1) demonstrated belonging to the East/Central/South African lineage
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hal-01239146 , version 1 (07-12-2015)



Nanikaly Moyen, Simon-Djamel Thiberville, Boris Pastorino, Antoine Nougairede, Laurence Thirion, et al.. First Reported Chikungunya Fever Outbreak in the Republic of Congo, 2011. PLoS ONE, 2014, 9 (e115938 ), ⟨10.1371/journal.pone.0115938⟩. ⟨hal-01239146⟩


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