Extreme multifunctional proteins identified from a human protein interaction network. - Aix-Marseille Université Access content directly
Journal Articles Nature Communications Year : 2015

Extreme multifunctional proteins identified from a human protein interaction network.

Abstract

Moonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of 'extreme multifunctional' proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct subgroup of proteins, characterized by specific features, which form a signature of extreme multi-functionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.
Fichier principal
Vignette du fichier
2015_ncomms8412.pdf (411.84 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01407399 , version 1 (18-04-2018)

Identifiers

Cite

Charles E Chapple, Benoît Robisson, Lionel Spinelli, Celine Guien, Becker Emmanuelle, et al.. Extreme multifunctional proteins identified from a human protein interaction network.. Nature Communications, 2015, 6 (1), pp.7412. ⟨10.1038/ncomms8412⟩. ⟨hal-01407399⟩
56 View
128 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More