Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion - Aix-Marseille Université Access content directly
Journal Articles Cell Reports Year : 2018

Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion

Rémi Bos
Ronald M Harris-Warrick
  • Function : Author
Liliia Demianenko
  • Function : Author
Sergiy M Korogod

Abstract

Graphical Abstract Highlights d Neonatal and adult bistable motoneurons display delayed spike-frequency acceleration d Delayed spike-frequency acceleration reflects slow inactivation of Kv1.2 channels d Kv1.2 channels are highly expressed in axon initial segments of motoneurons d Slow inactivation of Kv1.2 channels amplifies motor outputs upon locomotion onset In Brief Bos et al. demonstrate that slow inactivation of Kv1.2 channels is critical in shaping nonlinear firing properties in mammalian spinal cord. It provides a potent gain control mechanism in spinal motoneurons and has a behavioral role in enhancing locomotor drive during the transition from immobility to steady-state locomotion.

Domains

Neurobiology
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Dates and versions

hal-01791109 , version 1 (14-05-2018)

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Cite

Rémi Bos, Ronald M Harris-Warrick, Cécile Brocard, Liliia Demianenko, Marin Manuel, et al.. Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion. Cell Reports, 2018, 22 (12), pp.3315 - 3327. ⟨10.1016/j.celrep.2018.02.093⟩. ⟨hal-01791109⟩
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