Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma - Aix-Marseille Université
Article Dans Une Revue Nature Immunology Année : 2021

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot (1, 2) , Cyril Seillet (1, 3) , Minyu Wang (4, 3) , Angela Pizzolla (4, 3) , Yang Liao (1, 3, 5, 6) , Soroor Hediyeh-Zadeh (1, 3) , Sharon Grisaru-Tal (7) , Cynthia Louis (1, 3) , Qiutong Huang (1, 3, 8) , Jaring Schreuder (8) , Fernando Souza-Fonseca-Guimaraes (8) , Carolyn de Graaf (1, 3) , Kevin Thia (4) , Sean Macdonald (4) , Mary Camilleri (1, 3) , Kylie Luong (1, 3) , Shengbo Zhang (1, 3) , Michael Chopin (1, 3) , Tristan Molden-Hauer (4) , Stephen Nutt (1, 3) , Viktor Umansky (9, 10) , Bogoljub Ciric (11) , Joanna Groom (1, 3) , Paul Foster (12) , Philip Hansbro (12, 13, 14) , Andrew Mckenzie (15) , Daniel Gray (1, 3) , Andreas Behren (5, 6, 3) , Jonathan Cebon (5, 6, 3, 16) , Eric Vivier (17, 18, 19) , Ian Wicks (1, 3) , Joseph Trapani (4, 3) , Ariel Munitz (7) , Melissa Davis (1, 3) , Wei Shi (1, 5, 6, 3) , Paul Neeson (3, 4) , Gabrielle Belz (1, 3, 8)
1 WEHI - The Walter and Eliza Hall Institute of Medical Research
2 Princess Margaret Cancer Centre [Toronto, Canada]
3 University of Melbourne
4 Peter MacCallum Cancer Centre [Melbourne, Australie]
5 Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]
6 La Trobe University
7 TAU - Tel Aviv University
8 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
9 DKFZ - German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
10 Ruprecht-Karls Universität Heidelberg = Ruprecht-Karls University
11 Jefferson (Philadelphia University + Thomas Jefferson University)
12 UoN - University of Newcastle [Callaghan, Australia]
13 Centenary Institute [Sidney]
14 UTS - University of Technology Sydney
15 LMB - MRC Laboratory of Molecular Biology [Cambridge, UK]
16 Ludwig Institute for Cancer Research
17 CIML - Centre d'Immunologie de Marseille - Luminy
18 Innate Pharma
19 TIMONE - Hôpital de la Timone [CHU - APHM]
Nicolas Jacquelot
The Walter and Eliza Hall Institute of Medical Research
Princess Margaret Cancer Centre [Toronto, Canada]
Cyril Seillet
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Minyu Wang
  • Fonction : Auteur
Peter MacCallum Cancer Centre [Melbourne, Australie]
University of Melbourne
Angela Pizzolla
Peter MacCallum Cancer Centre [Melbourne, Australie]
University of Melbourne
Yang Liao
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]
La Trobe University
Soroor Hediyeh-Zadeh
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Sharon Grisaru-Tal
  • Fonction : Auteur
Tel Aviv University
Cynthia Louis
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Qiutong Huang
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
The University of Queensland
Jaring Schreuder
The University of Queensland
Fernando Souza-Fonseca-Guimaraes
  • Fonction : Auteur
The University of Queensland
Carolyn de Graaf
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Kevin Thia
  • Fonction : Auteur
Peter MacCallum Cancer Centre [Melbourne, Australie]
Sean Macdonald
  • Fonction : Auteur
Peter MacCallum Cancer Centre [Melbourne, Australie]
Mary Camilleri
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Kylie Luong
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Shengbo Zhang
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Michael Chopin
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Tristan Molden-Hauer
  • Fonction : Auteur
Peter MacCallum Cancer Centre [Melbourne, Australie]
Stephen Nutt
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Viktor Umansky
  • Fonction : Auteur
German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg]
Ruprecht-Karls Universität Heidelberg = Ruprecht-Karls University
Bogoljub Ciric
  • Fonction : Auteur
Jefferson (Philadelphia University + Thomas Jefferson University)
Joanna Groom
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Paul Foster
  • Fonction : Auteur
University of Newcastle [Callaghan, Australia]
Philip Hansbro
University of Newcastle [Callaghan, Australia]
Centenary Institute [Sidney]
University of Technology Sydney
Andrew Mckenzie
MRC Laboratory of Molecular Biology [Cambridge, UK]
Daniel Gray
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Andreas Behren
  • Fonction : Auteur
Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]
La Trobe University
University of Melbourne
Jonathan Cebon
  • Fonction : Auteur
Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]
La Trobe University
University of Melbourne
Ludwig Institute for Cancer Research
Eric Vivier
Centre d'Immunologie de Marseille - Luminy
Innate Pharma
Hôpital de la Timone [CHU - APHM]
CV
Ian Wicks
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Joseph Trapani
  • Fonction : Auteur
Peter MacCallum Cancer Centre [Melbourne, Australie]
University of Melbourne
Ariel Munitz
Tel Aviv University
Melissa Davis
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Wei Shi
  • Fonction : Auteur
The Walter and Eliza Hall Institute of Medical Research
Olivia Newton-John Cancer Research Institute [Heidelberg, VIC, Australia]
La Trobe University
University of Melbourne
Paul Neeson
University of Melbourne
Peter MacCallum Cancer Centre [Melbourne, Australie]
Gabrielle Belz
The Walter and Eliza Hall Institute of Medical Research
University of Melbourne
The University of Queensland

Résumé

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little about their underlying mechanisms or whether they could be clinically relevant or targeted to improve patient outcomes. Here, we found that high ILC2 infiltration in human melanoma was associated with a good clinical prognosis. ILC2s are critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinates the recruitment and activation of eosinophils to enhance antitumor responses. Tumor-infiltrating ILC2s expressed programmed cell death protein-1, which limited their intratumoral accumulation, proliferation and antitumor effector functions. This inhibition could be overcome in vivo by combining interleukin-33-driven ILC2 activation with programmed cell death protein-1 blockade to significantly increase antitumor responses. Together, our results identified ILC2s as a critical immune cell type involved in melanoma immunity and revealed a potential synergistic approach to harness ILC2 function for antitumor immunotherapies.

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Sciences du Vivant [q-bio]
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https://amu.hal.science/hal-03566011

Soumis le : mercredi 11 décembre 2024-16:00:03

Dernière modification le : jeudi 12 décembre 2024-17:06:59

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hal-03566011 , version 1 (11-12-2024)

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Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, et al.. Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 2021, 22 (7), pp.851-864. ⟨10.1038/s41590-021-00943-z⟩. ⟨hal-03566011⟩

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