Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment
Abstract
Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining di erent redoxeconomical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a siteselective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.
Origin : Files produced by the author(s)
Licence : Public Domain
Licence : Public Domain